Prompt injection lives and dies inside a single turn. Memory poisoning does not. An attacker gets instruction-like text into something the agent reads (a document, an email, a webpage, a tool response), the agent summarizes it into long-term memory during its normal write-back step, and days or weeks later a different user's query retrieves that entry and the agent follows it as if it were its own learned knowledge. The injection and the damage are temporally decoupled, which means per-request monitoring sees two normal events and nothing in between as this analysis of persistent memory poisoning sets out.
The mechanics are well documented. An agent treats retrieved memory as ground truth, so poisoned entries bypass the skepticism applied to fresh external input according to WorkOS's account of the attack surface. MITRE ATLAS catalogs adversarial manipulation of inputs and data used by AI components, which gives you a structured way to trace how a manipulation at the tool or document layer propagates into stored context per Trussed's runtime defense writeup. Empirical work is blunter: a systematic study of memory poisoning identifies four write channels and nine structural vulnerabilities that make those channels exploitable, and finds that agents tuned to write and retrieve memory more aggressively are more exploitable in the arXiv paper.
The practical consequence: "we have prompt injection defenses" is not an answer. The same study reports that existing prompt injection defenses do not cover memory poisoning attacks.



