The hard part of a recurring security review is not the review itself. It is deciding when to run one. If every commit triggers a full review, the process collapses under its own weight. If nothing does, the agent drifts away from the version that was actually reviewed.
The useful test is simple: a change is material if it can alter the set of actions the agent can take, the data it can reach, the people who can influence its goals, or the trail you would follow after an incident. Apply that test to six areas.
Prompts and system instructions. A new tool description, a loosened refusal rule, a changed persona or a reordered instruction hierarchy can all change behavior. OWASP's prompt injection guidance notes that LLMs do not reliably separate trusted instructions from untrusted data, so any edit that blurs that line matters. The OWASP Top 10 for Agentic Applications lists agent goal hijack as a top risk precisely because small prompt changes can redirect intent (OWASP Top 10 for Agentic Applications).
Tools and connectors. Adding a tool, granting a new OAuth scope, or changing the parameters a tool accepts all widen the blast radius. The Frontier Model Forum's issue brief treats tool authorization as one of the core layers of agent security, alongside the model itself and the harness around it (Frontier Model Forum).
Memory and retrieval. Changes to what the agent writes to long-term memory, how retrieval is filtered, or which documents feed the vector store all affect what a future session inherits. A poisoned memory write can outlive the session that produced it.
Model or provider. Swapping models, changing temperature, enabling a tool-calling mode or moving to a hosted endpoint can change how rigidly the agent follows its instructions.
Agent graph and delegation. Adding a sub-agent, changing routing logic or letting one agent pass instructions to another creates a trust boundary that did not exist before. Detection at Scale's practitioner write-up on threat modeling with MCP emphasizes that context and tooling paths are where attack paths concentrate (Detection at Scale).
Credentials, permissions and network reach. A broader API key, a new service account, an egress rule or a change to what the agent can call is always material, regardless of how small the diff looks.
A useful rule: if the change would require a new line in the tool inventory section of a security review document, it is material.



