Researchers increasingly treat too much sitting as a different problem from too little exercise. A review in Exercise and Sport Sciences Reviews put the idea plainly: too much sitting is distinct from too little exercise. Its authors found that even among adults who met physical activity guidelines, more TV time was associated with larger waists, higher blood pressure and worse blood sugar measures.
Larger studies point the same way. A cohort study in JAMA Network Open followed 481,688 people for a mean of almost 13 years. It found that people who mostly sat at work had a 16% higher risk of death from all causes and a 34% higher risk of death from cardiovascular disease than those who mostly did not, after adjusting for factors such as age, smoking and body mass index. The same study found that alternating between sitting and not sitting at work, or adding 15 to 30 minutes of leisure-time physical activity per day, attenuated those risks.
Mayo Clinic summarizes an analysis of 13 studies covering more than 1 million people: those who sat more than eight hours a day with no physical activity had a risk of dying similar to that posed by obesity and smoking, while 60 to 75 minutes of moderate activity a day offset the effect.
Harvard epidemiologist I-Min Lee adds a caution. In an interview with the Harvard T.H. Chan School of Public Health, she said there is a dose-response relationship and that physical activity may be insufficient to completely offset the increased risks of being sedentary. The practical message is to do both: exercise and sit less.



